新产品编号:397591

Chemical Name: 2-Oxo-N-[1(R)-Phenylethyl]-4-(2-pyridinylmethylsulfanyl)azetidine-1-carboxamide
CAS No. 210492-77-6
项目整合开发状态: Biological Testing
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:The acylation of 2-pyridylmethanol (I) with thioacetic acid (II) by means of Ph3P and DEAD in THF gives the corresponding thioacetate (III),which is condensed with 4-acetoxyazetidin-2-one (IV) by means of NaOH in methanol yielding 4-(2-pyridylmethylsulfanyl)azetidin-2-one (V).Finally,this compound is condensed with 1(R)-phenylethyl isocyanate (VI) by means of Et3N and DMAP in dichloromethane.