CO-122739
Chemical Name: 3alpha-Hydroxy-3-methyl-21-(sulfosulfanyl)-5alpha-pregnan-20-one sodium salt
CAS No. 171493-96-2
项目整合开发状态: Preclinical
项目研究机构: CoCensys (Originator)
合成路线:The bromination of 3-alpha-hydroxy-3-beta-methyl-5-alpha-pregnan-20-one (I) with Br2 in acidic methanol gives the 21-bromo derivative (II),which is then treated with sodium thiosulfate in ethanol/water.
📌 参考资料/链接：
参考文献标题:Androstanes and pregnanes for allosteric modulation of GABA receptor
文献作者:Upasani,R.B.; Xia,H.; Hogenkamp,D.(CoCensys,Inc.)
参考来源:EP 0752860; EP 1038880; JP 1997510701; WO 9521617
📄 详细内容
合成路线:The bromination of 3-alpha-hydroxy-3-beta-methyl-5-alpha-pregnan-20-one (I) with Br2 in acidic methanol gives the 21-bromo derivative (II),which is then treated with sodium thiosulfate in ethanol/water.
参考文献标题:Sodium S-(3alpha-hydroxypregnan-20-on-21-yl)thiosulfates: Allosteric modulators of the GABAA receptor
文献作者:Acosta-Burruel,M.; Hawkinson,J.E.; Fick,D.B.; et al.
参考来源:217th ACS Natl Meet (March 21 1999,Anaheim) 1999,Abst MEDI 098