新产品编号:25821

Chemical Name: 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[4-(2,3,4-trimethoxybenzyl)piperazin-1-ylcarbonylmethoxy]-4H-benzopyran-4-one
CAS No. 123580-63-2, 123580-64-3 (methanesulfonate)
项目整合开发状态: Biological Testing
项目研究机构: Servier (Originator)
合成路线:The reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with ethyl piperazine-1-carboxylate (II) by means of NaBH3CN in AcOH gives the corresponding benzyl derivative (III),which is decarboxylated with aqueous KOH at 130 C yielding 1-(2,3,4-trimethoxybenzyl)piperazine (IV).The acylation of (IV) with chloroacetyl chloride in dichloromethane affords 1-(2-chloroacetyl)-4-(2,3,4-trimethoxybenzyl)piperazine (V).,which is finally condensed with diosmetin (VI) by means of KHCO3 in DMF.