MEN-11575

Chemical Name: (2S,3aS,7aS)-1-[2-[11-(D-Arginyl-L-arginylamino)undecanoyl-L-seryl]-1,2,3,4-tetrahydroisoquinolin-3(R)-ylcarbonyl]perhydroindole-2-carboxylic acid
CAS No. 222165-43-7
项目整合开发状态: Biological Testing
项目研究机构: Menarini (Originator)
合成路线:This pseudopeptide has been synthesized by the solid phase method using a 2-chlorotrityl chloride resin (II) and doing successive cycles of deprotection and coupling with the protected amino acids or pseudoamino acids (I),(IV),(VI),(VIII),(X),and (XII),yielding successively the resins (III),(V),(VII),(IX),(XI) and (XIII).Finally,the last resin (XIII) is deprotected as usual and the peptide cleaved form the resin with TFA,phenol,thioanisole and ethanedithiol.