PF-9404C, PF-9404

Chemical Name: 1-[4-[2(S),3-Bis(nitrooxy)propoxymethyl]phenoxy]-3-(isopropylamino)propan-2(S)-ol
CAS No. 164340-32-3 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Almirall Prodesfarma (Originator)
合成路线:Alkylation of 4-[2,3-dinitroxy)propoxymethyl]phenol (I) with epichlorhydrin (II) in the presence of NaOH provided the corresponding epoxypropoxy derivative (III).Then,epoxide opening with isopropylamine (IV) in refluxing MeOH furnished the desired amino alcohol.