Moveltipril calcium, Altiopril calcium, MC-838, Lowpress
莫维普利钙 莫维普利 Chemical Name: 1-[3-[[2(R)-[(Cyclohexylcarbonyl)amino]-1-oxopropyl]thio]-2(S)-methyl-1-oxopropyl]-L-proline calcium salt(2:1)
CAS No. 85921-53-5, 85856-54-8 (free base)
项目整合开发状态: Pre-Registered
项目研究机构: Chugai (Originator)
合成路线:The reaction of N-(cyclohexanecarbonyl)-D-alanine (I) with 3-mercapto-2-methylpropanoic acid (II) by means of carbonyldiimidazole (III) in THF gives 3-[N-(cyclohexanecarbonyl)-D alanilthio]-2-methyl-propanoic acid (IV),which is then condensed with L-protine (V) by means of triethylamine and ethyl chloroformate (VI) o THF.
📌 参考资料/链接：
参考文献标题:Proline derivative
文献作者:Iwaoka,T.; Kuromaru,K.; Obatake,N.; Hata,S.I.; Matsunaga,I.; Fujimura,Y.; Aono,J.; Hinohara,Y.; Fukushima,M.; Nabata,H.; Sakai,K.; Tanaka,S.; Nakano,H.(Chugai Pharmaceutical Co.Ltd.)
参考来源:BE 0893553; JP 1982209270; JP 1988045252
📄 详细内容
合成路线:The reaction of N-(cyclohexanecarbonyl)-D-alanine (I) with 3-mercapto-2-methylpropanoic acid (II) by means of carbonyldiimidazole (III) in THF gives 3-[N-(cyclohexanecarbonyl)-D alanilthio]-2-methyl-propanoic acid (IV),which is then condensed with L-protine (V) by means of triethylamine and ethyl chloroformate (VI) o THF.
参考文献标题:MC-838
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(5),380
产品链接: CAS No. 85921-53-5›› 产品链接: CAS No.85856-54-8››