新产品编号:525733

Chemical Name: [1R,9S,12S(1'R,3'R,4'R),13R,14S,17R,21S,23S,24R,25S,27R]-17-Ethyl-1,14-dihydroxy-23,25-dimethoxy-12-[2(E)-[3-methoxy-4-(3-phenylcarbazoyloxy)cyclohexyl]-1-methylvinyl]-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0(4,9)]octacos-18(E)-ene-2,3,10,16-tetraone
CAS No. 220873-56-3
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:The title compound was obtained by treatment of ascomycin (I) with triphosgene and 4-dimethylaminopyridine at -78 C to produce selectively the 32-hydroxyl mono-acylated product (II),which was subsequently condensed with phenylhydrazine yielding the target phenylcarbazate.