CT-5219

Chemical Name: N-Acetyl-4-thia-D-prolyl-[4-O-(2,6-dichlorobenzyl)]-L-tyrosine; N-[3-Acetyl-4(S)-thiazolidinylcarbonyl]-L-[4-O-(2,6-dichlorobenzyl)]-tyrosine
CAS No. 217478-98-3
项目整合开发状态: Preclinical
项目研究机构: Celltech (Originator)
合成路线:Coupling of N-acetyl-D-thioproline (I) with tyrosine methyl ester (II) using EDC and HOBt yielded dipeptide (III).Subsequent alkylation of the tyrosine phenolic group of (III) with 2,6-dichlorobenzyl bromide (IV) and NaH produced the dichlorobenzyl ether (V).The methyl ester group of (V) was finally hydrolyzed employing LiOH in aqueous THF.