新产品编号:910159
Chemical Name: 5-Methoxy-1-phenyl-1H-benzimidazole
CAS No. 38205-85-5
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:The reaction of 2-chloro-5-methoxynitrobenzene (I) with aniline (II) in basic medium gives the diphenylamine (III),which is reduced at the NO2 group with H2 over Pd/C in methanol yielding the o-phenylenediamine (IV).Finally,this compoud is cyclized with formamidine (V) in refluxing 2-methoxyethanol.
📌 参考资料/链接：
参考文献标题:Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor
文献作者:Palmer,B.D.; Smaill,J.B.; Boyd,M.; Boschelli,D.H.; Doherty,A.M.; Hamby,J.M.; Khatana,S.S.; Kramer,J.B.; Kraker,A.J.; Panek,R.L.; Lu,G.H.; Dahring,T.K.; Winters,R.T.; Showalter,H.D.; Denny,W.A.
参考来源:J Med Chem 1998,41(27),5457