新产品编号:505167

Chemical Name: 2-Methylpropionic acid 2-(2-amino-6-fluoro-9H-purin-9-ylmethoxy)ethyl ester
CAS No. 220150-71-0
项目整合开发状态: Preclinical
项目研究机构: SK Chemicals (Originator)
合成路线:Treatment of the 6-chloropurine (I) with trimethylamine in DMF-THF produced the intermediate ammonium salt (II),which was displaced by KF in DMF at 80 C to afford fluoride (III).Finally,esterification of (III) with isobutyric anhydride in the presence of DMAP yielded the title isobutyrate ester.