GPI-6150

Chemical Name: 1,11b-Dihydro-1-benzopyrano[4,3,2-de]isoquinolin-3(2H)-one
CAS No. 220938-17-0
项目整合开发状态: Preclinical
项目研究机构: Guilford Pharmaceuticals (Originator)
合成路线:Reduction of 9-xanthencarboxamide (I) employing NaBH4 and acetic acid in boiling dioxan yielded the primary amine (II).This was treated with triphosgene to produce isocyanate (III).Finally,cyclization of the isocyanate (III) in hot polyphosphoric acid furnished the title tetracyclic system.