YJA-20379-8

Chemical Name: (+)-1-[8-Ethoxy-4-[1(R)-phenylethylamino]-1,7-naphthyridin-3-yl]-1-butanone
CAS No. 187654-40-6
项目整合开发状态: Preclinical
项目研究机构: Yung-Jin (Originator)
合成路线:The condensation of 2-methoxypyridine-3-amine (I) with ethyl 2-(ethoxymethylene)-3-oxohexanoate (II) by heating at 120-30 C gives the aminoacrylate ewster (III),which is cyclized by heating in refluxing diphenyl ether to yield the naphthyridinone (IV).The reaction of (IV) with methanesulfonyl chloride and triethylamine in dichloromethane affords the methanesulfonyloxy naphthyridine (V),which is finally condensed with (R)-1-phenylethylamine (VI) in refluxing acetonitrile.