新产品编号:392845
Chemical Name: Bis(3,3-dimethylglutaric acid) 3beta,28-dihydroxylup-20(29)-en-3,28-diyl diester ; [1R(1alpha,3aalpha,5aalpha,5bbeta,7aalpha,9beta,11aalpha,11balpha,13abeta,13balpha)]-3a-(Hydroxymethyl)-1-isopropenyl-5a,5b,8,8,11a-pentamethylperhydrocyclopenta[a]chrysen-9-ol 3a,9-O-bis(3,3-dimethylglutaric acid monoester)
CAS No. 209798-85-6
项目整合开发状态: Biological Testing
项目研究机构: Biotech Research Laboratories (Originator), Boston Biomedica (Originator), University of North Carolina (Originator)
合成路线:The target diester was obtained by condensation of betulin (I) with an excess of 3,3-dimethyl glutaric anhydride (II) in the presence of 4-(dimethylamino)pyridine in pyridine at 95 C.
📌 参考资料/链接：
参考文献标题:Acylated betulin and dihydrobetulin derivs.,preparation thereof and use thereof
文献作者:Sun,I.-C.; Cosentino,L.M.; Lee,K.-H.; Wang,H.-K.(BBI Biotech Research Laboratories,Inc.; University of North Carolina)
参考来源:US 6172110
📄 详细内容
合成路线:The target diester was obtained by condensation of betulin (I) with an excess of 3,3-dimethyl glutaric anhydride (II) in the presence of 4-(dimethylamino)pyridine in pyridine at 95 C.
参考文献标题:Anti-AIDS agents.34.Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents
文献作者:Sun,I.-C.; Wang,H.-K.; Kashiwada,Y.; Shen,J.-K.; Cosentino,L.M.; Chen,C.-H.; Yang,L.-M.; Lee,K.-H.
参考来源:J Med Chem 1998,41(23),4648
合成路线:The target diester was obtained by condensation of betulin (I) with an excess of 3,3-dimethyl glutaric anhydride (II) in the presence of 4-(dimethylamino)pyridine in pyridine at 95 C.
参考文献标题:Anti-AIDS agents.32.Synthesis and anti-HIV activity of betulin derivatives
文献作者:Sun,I.C.; Shen,J.K.; Wang,H.K.; Cosentino,L.M.; Lee,K.H.
参考来源:Bioorg Med Chem Lett 1998,8(10),1267-1272