SL-88.0338

Chemical Name: 2-[1-(3-Ethoxybenzoyl)piperidin-4-ylmethyl]-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No. 214693-17-1
项目整合开发状态: Preclinical
项目研究机构: Sanofi-Aventis (Originator)
合成路线:Reduction of ethyl 4-piperidinecarboxylate (I) with LiAlH4 in THF provided 4-piperidinemethanol (II),which was coupled with 3-ethoxybenzoyl chloride (III) in the presence of Et3N,yielding amide (IV).Subsequent treatment of (IV) with p-toluenesulfonyl chloride in pyridine afforded the corresponding tosylate (V.This was finally condensed with 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline (VI) to furnish the title compound.