新产品编号:176111

Chemical Name: 4-[3-(4-Ethynylphenoxy)propyl]-1H-imidazole maleate
CAS No. 184027-09-6, 184027-08-5 (free base)
项目整合开发状态: Preclinical
项目研究机构: Bioprojet (Originator), INSERM (Originator)
合成路线:4-Iodophenol (I) was protected as the trimethylsilyl ether (II) with Me3SiCl and then coupled with (trimethylsilyl)acetylene (III) using palladium catalyst and CuI to afford the O-desilylated ethynylphenol (IV).This was condensed under Mitsunobu conditions with N-Boc-imidazolylpropanol (VI),prepared from imidazolylpropanol (V) and Boc2O,to afford ether (VII).Deprotection of the Boc group of (VII) with methanolic hydrazine at r.t.yielded a mixture of (VIII) and the fully desilylated analogue (IX),which was isolated by column chromatography and finally crystallized as the maleate salt from EtOH-Et2O.