BRL-32872(free base), BRL-32872A

苯扎米,N-(3,4-二甲氧基苯基)-N-[3-[[[2-(3,4-二甲氧基苯基)乙基]甲基氨基]丙基]-4-硝基-盐酸盐(1:1) Chemical Name: N-(3,4-Dimethoxyphenyl)-N-[3-[N'-methyl-N'-[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-4-nitrobenzamide hydrochloride
CAS No. 113241-09-1 (free base), 113241-47-7 (monoHCl)
项目整合开发状态: Phase II
项目研究机构: GlaxoSmithKline (Originator)
合成路线:3-Chloropropionyl chloride (II) was condensed with 4-aminoveratrole (I) in the presence of triethylamine to give the chloropropionamide (III).Further alkylation of N-methyl-2-(3,4-dimethoxyphenyl)ethylamine (IV) with (III) in refluxing acetonitrile afforded the aminopropionamide (V),which was subsequently reduced to diamine (VI) with LiAlH4 in boiling THF.Finally,acylation of (VI) with 4-nitrobenzoyl chloride (VII) gave the target amide.