PD-171729

Chemical Name: N-Butyl-N-[3-(2,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl]-N-ethylamine
CAS No. 202579-59-7
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:The cyclization of 5-aminopyrazole (I) with ethyl acetoacetate (II) by means of p-tolulenesulfonic acid in refluxing toluene gives the pyrazolo-pyrimidinone (III),along with its undesired isomer that is separated by crystallization or chromatography.The reaction of (III) with POCl3 gives the chloro derivative (IV),which is finally condensed with butylethylamine (V).