L-818571

Chemical Name: 2-(Cyclopropylmethyl)-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyridazin-3(2H)-one
CAS No. 213763-92-9
项目整合开发状态: Preclinical
项目研究机构: Merck Frosst (Originator)
合成路线:Cyclization of hydroxyfuranone (I) with hydrazine in refluxing EtOH produced the pyridazinone (II),which was subsequently alkylated with cyclopropylmethyl bromide (III) in the presence of NaOH to afford the title compound.