XQ-786

Chemical Name: 2,2-Difluoro-2-(4-isobutylphenyl)-N-[6-methyl-2,4-bis(methylsulfanyl)-3-pyridinyl]acetamide
CAS No. 186024-90-8
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:The reaction of 2,2-difluoro-2-(4-isobutylphenyl)acetic acid (I) with oxalyl chloride in dichloromethane gives the corresponding acyl chloride (II),which is then treated with 6-methyl-2,4-bis(methylsulfanyl)pyridine-3-amine (III) and 4-(dimethylamino)pyridine (DMAP) in the same solvent.