DPP-CNDAC
Chemical Name: (R)-4-Amino-1-[5-O-[[2,3-bis(hexadecanoyloxy)propoxy]hydroxyphosphinyl]-2-cyano-2-deoxy-beta-D-arabinofuranosyl]-2(1H)-pyrimidinone monosodium salt; (R)-1-[5-O-[[2,3-Bis(hexadecanoyloxy)propoxy]hydroxyphosphinyl]-2-cyano-2-deoxy-beta-D-arabinofuranosyl]cytosine monosodium salt
CAS No. 178111-53-0, 171486-65-0 (free acid)
项目整合开发状态: Preclinical
项目研究机构: Sankyo (Originator)
合成路线:By transphosphatidylation between 1-(2-C-cyano-2-deoxy-beta-D-arabinofuranosyl)cytosine (I) and the 3-phosphatidylcholine (II) catalyzed by phospholypase D from Streptomyces sp.AA 586 in a two phase system of choroform and acetate buffer (pH 4.5) at 40 C.
📌 参考资料/链接：
参考文献标题:Nucleosides and nucleotides.150.Enzymatic synthesis of 5'-phosphatidyl derivatives of 1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl)cytosine (CNDAC) and their notable antitumor effects in mice
文献作者:Shuto,S.; et al.
参考来源:Bioorg Med Chem Lett 1996,6(9),1021