新产品编号:413411

Chemical Name: 2-[2-(4-Methoxy-3,5-dimethylpyridin-2-yl)ethyl-2-methyl-5-(trifluoromethyl)-2,3-dihydrobenzothiazole
CAS No. 212779-16-3
项目整合开发状态: Preclinical
项目研究机构: Il-Yang (Originator)
合成路线:Reaction of chloromethylpyridine (I) with NaOH in aqueous THF afforded alcohol (II),which was oxidized to formylpyridine (III) with selenium dioxide in refluxing pyridine.Subsequent condensation of aldehyde (III) with phosphorane (IV) in THF provided enone (V),and this was hydrogenated in the presence of Pd/C in MeOH to give (VI).Finally,condensation of ketone (VI) with aminothiophenol (VII) in the presence of p-toluenesulfonic acid in refluxing benzene yielded the corresponding benzothiazolidine.