GYKI-39521, RGH-1875
Chemical Name: 4-(5-Thio-beta-D-xylopyranosylsulfanyl)benzothioimidic acid S-methyl ester hydroiodide
CAS No. 214272-33-0, 201546-86-3 (free base)
项目整合开发状态: Preclinical
项目研究机构: Gedeon Richter (Originator)
合成路线:The reaction of Beciparcil (I) with H2S and triethylamine in pyridine gives the thiobenzamide (II),which is finally methylated with methyl iodide in refluxing acetone.
📌 参考资料/链接：
参考文献标题:An economic synthesis of 1,2,3,4-tetra-O-acetyl-5-thio-D-xylopyranose and its transformation into 4-substituted-phenyl 1,5-dithio-D-xylopyranosides possessing antithrombotic activity
文献作者:Bozo,E.; Boros,S.; Kuszmann,J.; Gacs-Baitz,E.; Parkanyi,L.
参考来源:Carbohydr Res 1998,308(3-4),297