CCT-62

Chemical Name: 6-(4-Methylene-5-oxo-2-phenyltetrahydrofuran-2-ylmethoxy)quinolin-2(1H)-one
CAS No. 210245-19-5
项目整合开发状态: Biological Testing
项目研究机构: Kaohsiung Medical University (Originator), National Taiwan University (Originator)
合成路线:6-Hydroxyquinolin-2-one (I) was O-alkylated with 2-bromoacetophenone (II) by means of K2CO3 to give the phenacyl ether (III).Then,a Reformatsky-type condensation of (III) with ethyl 2-(bromomethyl)acrylate (IV) and Zn,with concomitant cyclization,yielded the target methylenebutyrolactone.