YJA-20379-5

Chemical Name: 4,5-Dihydropyrido[1,2-a][1,3]thiazolo[5,4-g]benzimidazol-2-amine
CAS No. 187680-75-7
项目整合开发状态: Preclinical
项目研究机构: Yung-Jin (Originator)
合成路线:1,3-Cyclohexanedione (I) was brominated in cold water,and the resulting 2-bromo-1,3-cyclohexanedione (II) was condensed with 2-aminopyridine (III) in boiling EtOH to afford the dihydropyridobenzimidazolone (IV).Further bromination in concentrated HBr at 70 C gave bromoketone (V),which was finally condensed with thiourea (VI) in EtOH to yield the target tetracyclic compound.