Hexaprazol, Esaprazole hydrochloride, CO/1063, Praxol
艾沙拉唑Chemical Name: N-Cyclohexyl-1-piperazineacetamide hydrochloride
CAS No. 64204-55-3 (free base)
项目整合开发状态: Phase III
项目研究机构: Camillo Corvi (Originator)
合成路线:The reaction of cyclohexylamine (I) with chloroacetyl chloride (II) in water in the presence of sodium hydroxide gives N-cyclohexyl-2-chloro-acetamide (III),which by reaction with piperazine (IV) in water is converted to N-[(N-cyclohexylcarbamoyl)methyl]piperazine (V).This compound is then treated with one equivalent of HCl.
📌 参考资料/链接：
参考文献标题:N-Cyclohexyl-piperazino acetamides and propionamides
文献作者:Corvi-Mora,C.(Camillo Corvi SpA)
参考来源:US 4123530; US 4278796
📄 详细内容
合成路线:The reaction of cyclohexylamine (I) with chloroacetyl chloride (II) in water in the presence of sodium hydroxide gives N-cyclohexyl-2-chloro-acetamide (III),which by reaction with piperazine (IV) in water is converted to N-[(N-cyclohexylcarbamoyl)methyl]piperazine (V).This compound is then treated with one equivalent of HCl.
参考文献标题:Esaprazole hydrochloride
文献作者:de Angelis,L.
参考来源:Drugs Fut 1986,11(4),263
产品链接: CAS No. 64204-55-3››