新产品编号:240973
羧肽酶G2(CPG2)抑制剂Chemical Name: N-(4-Methoxyphenylsulfanylcarbonyl)-L-glutamic acid
CAS No. 192203-60-4, 192203-55-7 (undefined isomer)
项目整合开发状态: Biological Testing
项目研究机构: Protherics (Originator)
合成路线:The reaction of L-glutamic acid di tert-butyl ester (I) with 4-nitrophenyl chloroformate (II) by means of triethylamine in dichloromethane gives the corresponding carbamate (III),which is treated with 4-methoxythiophenol (IV) in dichloromethane to afford the thiocarbamate (V).Finally,this compound is treated with HCl.
📌 参考资料/链接：
参考文献标题:Drug therapy
文献作者:Khan,T.(Aepact Ltd.)
参考来源:WO 9720580
📄 详细内容
合成路线:The reaction of L-glutamic acid di tert-butyl ester (I) with 4-nitrophenyl chloroformate (II) by means of triethylamine in dichloromethane gives the corresponding carbamate (III),which is treated with 4-methoxythiophenol (IV) in dichloromethane to afford the thiocarbamate (V).Finally,this compound is treated with HCl.
参考文献标题:Novel inhibitors of carboxypeptidase G2 (CPG2): Potential use in antibody-directed enzyme prodrug therapy
文献作者:Khan,T.H.; Eno-Amooquaye,E.A.; Searle,F.; Browne,P.J.; Osborn,H.M.; Burke,P.J.
参考来源:J Med Chem 1999,42(6),951
产品链接: CAS No. 192203-60-4››