SU-5402

Chemical Name: (Z)-3-[4-Methyl-2-(2-oxo-3,4-dihydroindol-3-ylidenemethyl)pyrrol-3-yl]propionic acid
CAS No. 210303-49-4
项目整合开发状态: Preclinical
项目研究机构: Sugen (Originator)
合成路线:Vilsmeier reaction between 2,4-dimethylpyrrole (I) and dimethylformamide (II) by means of phosphorous oxychloride in dichloroethane provides carbaldehyde (III),which is then condensed with 2-indolinone (IV) in ethanol in the presence of piperidine.

合成路线:Title compound was prepared by condensation of oxindole (I) and formylpyrrole (II) in the presence of a catalytic amount of piperidine in refluxing EtOH.

合成路线:The reaction of 1-phenylpiperazine (I) with DMF and POCl3 in dichloroethane gives 4-(4-formylpiperazin-1-yl)benzaldehyde (II),which is condensed with indolin-2-one (III) by means of piperidine in refluxing ethanol.

合成路线:Aldehyde (II) was prepared by Vilsmeier-Haack formylation of 2,4-dimethylpyrrole (I).Subsequent condensation of the pyrrole aldehyde (II) with 5-chlorooxindole (III) in the presence of piperidine furnished the title compound.