新产品编号:335893
Chemical Name: 1,2,3,8-Tetrahydroindolizino[7,6,5-kl]acridinium chloride
CAS No. 203785-43-7
项目整合开发状态: Preclinical
项目研究机构: University of Bradford (Originator), University of Nottingham (Originator)
合成路线:Treatment of 9-chloroacridine (I) with NaN3 in aqueous acetone affords azidoacridine (II),which is submitted to a cycloaddition reaction with 5-chloro-1-pentynyl (III) to yield 9-(triazol-1-yl)acridine (IV).Finally,(IV) is cyclized by thermolysis in hot diphenyl ether.
📌 参考资料/链接：
参考文献标题:Antitumor polycyclic acridines.7.Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines
文献作者:Stanslas,J.; Hagan,D.J.; Ellis,M.J.; Turner,C.; Carmichael,J.; Ward,W.; Hammonds,T.R.; Stevens,M.F.G.
参考来源:J Med Chem 2000,43(8),1563