KN-734, CT-052923, CT-52923
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide
CAS No. 205256-55-9
项目整合开发状态: Preclinical
项目研究机构: Kyowa Hakko (Originator), Millennium (Codevelopment)
合成路线:The title thiourea derivative was prepared by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 1,3-benzodioxol-5-ylmethyl isothiocyanate (II) in refluxing ethanol.
合成路线:The title urea derivative was synthesized by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 4-bromophenyl isocyanate (II) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Nitrogenous heterocyclic cpds
文献作者:Matsuno,K.; Ichimura,M.; Nomoto,Y.; Fujiwara,S.; Ide,S.; Tsukuda,E.; Irie,J.; Oda,S.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0882717; WO 9814431
📄 详细内容
合成路线:The title thiourea derivative was prepared by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 1,3-benzodioxol-5-ylmethyl isothiocyanate (II) in refluxing ethanol.
参考文献标题:Potent and selective inhibitors of PDGF receptor phosphorylation.2.Synthesis,structure activity relationship,improvement of aqueous solubility,and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline deri
文献作者:Matsuno,K.; Nakajima,T.; Ichimura,M.; Giese,N.A.; Yu,J.C.; Lokker,N.A.; Ushiki,J.; Ide,S.-i.; Oda,S.; Nomoto,Y.
参考来源:J Med Chem 2002,45(20),4513
产品链接: CAS No. 205256-55-9››