L-167307
Chemical Name: 4-[2-(4-Fluorophenyl)-5-[4-(methylsulfinyl)phenyl]-1H-pyrrol-3-yl]pyridine
CAS No. 188352-45-6
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Originator)
合成路线:The condensation of pyridine-4-carbaldehyde (I) with 4-(methylsulfinyl)acetophenone (II) by means of diethylamine in pyridine gives the chalcone (III),which is treated with 4-fluorobenzaldehyde (IV) and NaCN in DMF to afford the butanedione (V).Finally,this compound is cyclized with ammonium acetate in refluxing acetic acid.
📌 参考资料/链接：
参考文献标题:2,5-Substd.aryl pyrroles,comspns.containing suc
文献作者:De Laszlo,S.E.; Mantlo,N.B.; Ponticello,G.S.; Selnick,H.G.; Liverton,N.J.(Merck & Co.,Inc.)
参考来源:EP 0871444; JP 1999510511; WO 9705878
📄 详细内容
合成路线:The condensation of pyridine-4-carbaldehyde (I) with 4-(methylsulfinyl)acetophenone (II) by means of diethylamine in pyridine gives the chalcone (III),which is treated with 4-fluorobenzaldehyde (IV) and NaCN in DMF to afford the butanedione (V).Finally,this compound is cyclized with ammonium acetate in refluxing acetic acid.
参考文献标题:Substd.aryl pyrroles,compsns.containing such cp
文献作者:De Laszlo,S.E.; Mantlo,N.B.(Merck & Co.,Inc.)
参考来源:WO 9716441
合成路线:The condensation of pyridine-4-carbaldehyde (I) with 4-(methylsulfinyl)acetophenone (II) by means of diethylamine in pyridine gives the chalcone (III),which is treated with 4-fluorobenzaldehyde (IV) and NaCN in DMF to afford the butanedione (V).Finally,this compound is cyclized with ammonium acetate in refluxing acetic acid.
参考文献标题:Pyrroles and other heterocycles as inhibitors of P
文献作者:de Laszlo,S.E.; Visco,D.; Agarwal,L.; Chang,L.; Chin,J.; Croft,G.; Forsyth,A.J.; Fletcher,D.S.; Frantz,B.; hacker,C.; Hanlon,W.A.; Harper,C.; Kostura,M.; Li,B.; Luell,S.; MacCoss,M.; mantlo,N.; O'Neill,E.A.; Orevillo,C.; et al.
参考来源:Bioorg Med Chem Lett 1998,8(19),2689
产品链接: CAS No. 188352-45-6››