新产品编号:291597
Chemical Name: 3-[2-(1-Piperidinyl)ethyl]-6-propylbenzothiazol-2(3H)-one
CAS No. 198056-28-9
项目整合开发状态: Preclinical
项目研究机构: National Institutes of Health (Originator), Universit?degli Studi di Bologna (Originator), Universit?Catholique de Louvain (Originator)
合成路线:Reaction of benzothiazolone (I) with propionyl chloride in the presence of triethylamine in refluxing THF provided the N-propionyl derivative (II),which was subsequently rearranged by heating at 165 C with AlCl3 to give ketone (III).Alkylation of (III) with 1-(2-chloroethyl)piperidine and K2CO3 in hot DMF yielded (IV),which was finally reduced with triethylsilane in trifluoroacetic acid to the propyl derivative.
📌 参考资料/链接：
参考文献标题:Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives
文献作者:Ucar,H.; Van Derpoorten,K.; Cacciaguerra,S.; Spampinato,S.; Stables,J.P.; Depovere,P.; Isa,M.; Masereel,B.; Delarge,J.; Poupaert,J.H.
参考来源:J Med Chem 1998,41(7),1138