YM-268

Chemical Name: 5,5'-Methylenebis(1,4-phenylene)bismethylenebis(thiazolidine-2,4-dione)
CAS No. 141716-96-3
项目整合开发状态: Preclinical
项目研究机构: Yamanouchi (Originator)
合成路线:Diazotization of 4,4'-diaminodiphenylmethane (I) with NaNO2 and HCl,followed by copper-catalyzed coupling with methyl acrylate afforded the alpha,alpha'-dichloro diester (II).Subsequent cyclization of (II) with thiourea (III) in refluxing EtOH produced the bis(iminothiazolidinone) (IV).Finally,acid hydrolysis of (IV) yielded the title compound.