LF-16.0335

Chemical Name: 4-[4-[1-[2,4-Dichloro-3-(2,4-dimethylquinolin-8-yloxymethyl)phenylsulfonyl]pyrrolidin-2(S)-ylcarbonyl]piperazin-1-ylcarbonyl]benzamidine dihydrochloride
CAS No. 202720-59-0, 202602-34-4 (free base)
项目整合开发状态: Biological Testing
项目研究机构: Fournier (Originator)
合成路线:Title compound was obtained by coupling the sulfonylprolylpiperazine derivative (I) with 4-amidinobenzoic acid (II) in the presence of EDC and HOBt in DMF,followed by conversion to the dihydrochloride salt.
📌 参考资料/链接:
参考文献标题:N-Benzenesulphonyl-L-proline derivs.as bradykinin B2 agonists
文献作者:Dodey,P.; Bondoux,M.; Houziaux,P.; Barth,M.; Ou,K.(Laboratoires Fournier SA)
参考来源:EP 0925295; US 6071917; WO 9803503