PP1D-1
Chemical Name: N-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)succinamic acid methyl ester
CAS No. 175090-76-3
项目整合开发状态: Preclinical
项目研究机构: China Medical College (Originator), National Taiwan University (Originator)
合成路线:Title compound was obtained by acylation of 2-amino-3-chloro-1,4-naphthoquinone (I) with 3-carbomethoxypropionyl chloride (II) in the presence of dry HCl in refluxing toluene.
📌 参考资料/链接：
参考文献标题:Synthesis and cytotoxicity of 1,2-disubstituted naphth[2,3-d]imidazole-4,9-diones and related compounds
文献作者:Kuo,S.-C.; Ibuka,T.; Huang,L.J.; Lien,J.C.; Yean,S.R.; Huang,S.C.; Lednicer,D.; Morris-Natschke,S.L.; Lee,K.H.
参考来源:J Med Chem 1996,39(7),1447-1451