CZ-48
Chemical Name: 4(S)-Ethyl-4-(propionyloxy)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione; 20(S)-(Propionyloxy)camptothecin
CAS No. 194414-69-2
项目整合开发状态: Preclinical
项目研究机构: Stehlin Foundation for Cancer Research (Originator)
合成路线:By esterification of camptothecin (I) with propionic anhydride in pyridine.
📌 参考资料/链接：
参考文献标题:Derivs.of camptothecin for use in treating cancer
文献作者:Ciovanella,B.C.; Zhisong,C.(The Stehlin Foundation for Cancer Research)
参考来源:EP 0879236; WO 9728165
📄 详细内容
合成路线:By esterification of camptothecin (I) with propionic anhydride in pyridine.
参考文献标题:Alkyl esters of camptothecin and 9-nitrocamptothecin: Synthesis,in vitro pharmacokinetics,toxicity,and antitumor activity
文献作者:Cao,Z.; Harris,N.V.; Kozielski,A.; Vardeman,D.; Stehlin,J.S.; Giovanella,B.
参考来源:J Med Chem 1998,41(1),31
产品链接: CAS No. 194414-69-2››