SWR-0315Na(oxalate salt), SWR-0342SA

Chemical Name: 2-[4-[1-[2-[2(S)-Hydroxy-3-phenoxypropylamino]ethyl]-1(Z)-propenyl]phenoxy]acetic acid oxalate; (Z)-2-[4-[1-Ethylidene-3-[2(S)-hydroxy-3-phenoxypropylamino]propyl]phenoxy]acetic acid oxalate
CAS No. 221079-56-7, 221080-12-2 (E-isomer), 221079-55-6 (free base), 221079-62-5 (non-specific stereoch.)
项目整合开发状态: Preclinical
项目研究机构: Sawai (Originator)
合成路线:Hydrazinolysis of phthalimido derivative (I) afforded amine (II),which was condensed with (phenoxymethyl)oxirane (III) in boiling isopropanol to give amino alcohol (IV).After hydrolysis of the tert-butyl ester group of (IV),the resultant compound (V) was converted to the title hemioxalate salt upon treatment with oxalic acid.