DMAMI

Chemical Name: N-(3,5-Dimethyladamantan-1-yl)maleimide; 1-(3,5-Dimethyladamantan-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
CAS No. 219135-20-3
项目整合开发状态: Preclinical
项目研究机构: National Taipei College of Nursing (Originator), National Taiwan University (Originator), National Yang-Ming University (Originator), Veterans General Hospital-Taipei (Originator)
合成路线:1-Bromo-3,5-dimethyladamantane (I) is subjected to Ritter reaction with acetonitrile in the presence of H2SO4 to produce acetamide (II).This is further hydrolyzed to the aminoadamantane (III) employing NaOH in refluxing diethyleneglycol.Condensation of amine (III) with maleic anhydride (IV) leads to the maleamic acid (V),which is finally cyclized to the target maleimide upon heating in acetic anhydride in the presence of NaOAc.