BIA-2-024
Chemical Name: 10(E)-(Hydroxyimino)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
CAS No. 199997-15-4
项目整合开发状态: Preclinical
项目研究机构: Bial (Originator), Portela (Originator)
合成路线:The title amide has been obtained by reaction of 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide (I) with hydroxylamine in refluxing pyridine.
📌 参考资料/链接：
参考文献标题:New derivs.of 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide
文献作者:Benes,J.; Soares da Silva,P.M.V.A.; Learmonth,D.A.(Portela & Ca.,SA)
参考来源:EP 0810216; JP 1998081669; US 5866566; WO 9745416
📄 详细内容
合成路线:The title amide has been obtained by reaction of 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide (I) with hydroxylamine in refluxing pyridine.
参考文献标题:Synthesis,anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives
文献作者:Learmonth,D.A.; Benes,J.; Parada,A.; Hainzl,D.; Beliaev,A.; Bonif醕io,M.J.; Matias,P.M.; Carrondo,M.A.; Garrett,J.; Soares-da-Silva,P.
参考来源:Eur J Med Chem 2001,36(3),227