EGIS-7625
Chemical Name: 5-(4-Benzylpiperazin-1-yl)-2-methyl-4-nitroaniline dihydrochloride
CAS No. 199671-60-8 (monoHCl)
项目整合开发状态: Preclinical
项目研究机构: Egis (Originator)
合成路线:The title compound was prepared by condensation between 1-benzylpiperazine (I) and 5-chloro-2-methyl-4-nitroaniline (II) in the presence of K2CO3 in either refluxing ethanol or,with a higher yield,in DMF at 120 C.Treatment with HCl in isopropanol furnished the corresponding dihydrochloride salt.
📌 参考资料/链接：
参考文献标题:Novel piperazine or homopiperazine derivs.,pharmaceutical compsns.containing the same and a process for their preparation
文献作者:R醫zn?Simonek,I.; B髗sing,D.; Jak骳zi,I.; Kov醤yin?Lax,G.; Blask? G.; Simig,G.; Gacs醠yi,I.; Schmidt,E.; Mikl髎n?Kov醕s,A.; Szirtn?Kiszelly,E.; Sz閚醩i,G.; Gyerty醤,I.; Egyed,A.; Tihanyi,K.(Egis Pharmaceuticals Ltd.)
参考来源:WO 9744334