NGB-2849

Chemical Name: N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]biphenylene-2-carboxamide
CAS No. 198555-28-1
项目整合开发状态: Biological Testing
项目研究机构: Neurogen (Originator)
合成路线:Dichlorophenylpiperazine (III) was prepared from aniline (I) by dehydrative cyclization with diethanolamine (II) in the presence of P2O5 and Et3N-HCl at 200 C.Alkylation of piperazine (III) with N-(4-bromobutyl) phthalimide (IV) gave (V),and subsequent hydrazinolysis of the phthalimide provided the (4-aminobutyl)piperazine (VI).Finally,condensation of (VI) with fluorene-2-carboxylic acid (VII) yielded the target amide.

合成路线:Dichlorophenylpiperazine (III) was prepared from aniline (I) by dehydrative cyclization with diethanolamine (II) in the presence of P2O5 and Et3N-HCl at 200 C.Alkylation of piperazine (III) with N-(4-bromobutyl) phthalimide (IV) gave (V),and subsequent hydrazinolysis of the phthalimide provided the (4-aminobutyl)piperazine (VI).Finally,condensation of (VI) with biphenylene-2-carboxylic acid (VII) yielded the target amide.