Ro-11-1464

Chemical Name: 9-Methyl-4-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS No. 54123-09-0
项目整合开发状态: Preclinical
项目研究机构: Roche (Originator)
合成路线:Treatment of diazepinone (I) with phosphorus pentasulfide in refluxing pyridine affords diazepinethione (II).Subsequent reaction with acetyl hydrazine in refluxing n-butanol gives the intermediate acetylhydrazino compound (III),which on prolonged heating cyclizes to the desired triazolodiazepine.