S-18841
Chemical Name: 3-Hydroxyimidazolidin-4-one
CAS No. 192565-05-2
项目整合开发状态: Preclinical
项目研究机构: ADIR (Originator)
合成路线:Ethyl glycinate (I) was converted to the 2-aminoacetohydroxamic acid (II) by reaction with hydroxylamine in the presence of KOH in aqueous MeOH.Subsequent cyclization of (II) upon treatment with formaldehyde provided the target 3-hydroxyimidazolin-4-one.
📌 参考资料/链接：
参考文献标题:4-Imidazolidinone cpds.
文献作者:Cordi,A.; Lacoste,J.-M.; Millan,M.; Audinot,V.(ADIR et Cie.)
参考来源:EP 0780379; US 5677325
📄 详细内容
合成路线:Ethyl glycinate (I) was converted to the 2-aminoacetohydroxamic acid (II) by reaction with hydroxylamine in the presence of KOH in aqueous MeOH.Subsequent cyclization of (II) upon treatment with formaldehyde provided the target 3-hydroxyimidazolin-4-one.
参考文献标题:Design,synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands
文献作者:Cordi,A.; Lacoste,J.-M.; Audinot,V.; Millan,M.
参考来源:Bioorg Med Chem Lett 1999,9(10),1409
产品链接: CAS No. 192565-05-2››