新产品编号:274195
Chemical Name: 9-Fluoro-5-methyl-1-oxo-N-[2-(4-pyridyl)ethyl]-6,7-dihydro-1H,5H-benzo[ij]quinolizine-2-carboxamide hydrochloride
CAS No. 195191-82-3
项目整合开发状态: Preclinical
项目研究机构: Celltech (Originator)
合成路线:Title compound was obtained from flumequine (I) by treatment with isopropenyl chloroformate (II) and triethylamine,followed by condensation of the resulting mixed anhydride (III) with 2-(4-pyridyl)ethylamine (IV).
📌 参考资料/链接：
参考文献标题:Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors.A potential treatment for asthma
文献作者:Beasley,S.C.; Cooper,N.; Gowers,L.; Gregory,J.P.; Haughan,A.F.; Hellewell,P.G.; Macari,D.; Miotla,J.; Montana,J.G.; Morgan,T.; Naylor,R.; Runcie,K.A.; Tuladhar,B.; Warneck,J.B.
参考来源:Bioorg Med Chem Lett 1998,8(19),2629