GR-215864X, GW-215864X

Chemical Name: 6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-(propionyloxy)androsta-1,4-diene-17beta-carbothioic acid S-[2-oxotetrahydrofuran-3(R)-yl] ester
CAS No. 192056-79-4 ((R)-isomer), 192056-77-2 ((S)-isomer)
项目整合开发状态: Phase II
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Treatment of carboxylic acid (I) with diethyl chlorophosphate (II) in the presence of Et3N furnished the corresponding mixed anhydride (III).This was then condensed with the sodium salt of alpha-mercapto-gamma-butyrolactone (IV) to produce the title thioester.

合成路线:The title compound was prepared by condensation of the carbothioic acid (I) with alpha-bromo-gamma-butyrolactone (II) in the presence of K2CO3 in DMF.