SIB-1553A
Chemical Name: (?-2-[2-(4-Hydroxyphenylsulfanyl)ethyl]-1-methylpyrrolidine hydrochloride
CAS No. 191611-76-4 (free base)
项目整合开发状态: Phase II
项目研究机构: Merck & Co. (Originator)
合成路线:The condensation of 4-hydroxythiophenol (I) with 2-(2-chloroethyl)-1-methylpyrrolidine (II) in the presence of K2CO3 in DMF afforded the title thioether,which was isolated as the hydrochloride salt.
📌 参考资料/链接：
参考文献标题:Novel substd.aryl cpds.useful as modulators of acetylcholine receptors
文献作者:Vernier,J.M.; McDonald,I.A.(SIBIA Neurosciences,Inc.)
参考来源:EP 0874818; JP 2000501080; WO 9719059
📄 详细内容
合成路线:The condensation of 4-hydroxythiophenol (I) with 2-(2-chloroethyl)-1-methylpyrrolidine (II) in the presence of K2CO3 in DMF afforded the title thioether,which was isolated as the hydrochloride salt.
参考文献标题:4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): A novel cognitive enhance with selectivity for neuronal nicotinic acetylcholine receptors
文献作者:Vernier,J.M.; El-Abdellaoul,H.; Holsenback,H.; Cosford,N.D.; Bleicher,L.; Barker,G.; Bontempi,B.; Chavez-Noriega,L.; Menzaghi,F.; Rao,T.S.; Reid,R.; Sacaan,A.I.; Suto,C.; Washburn,M.; Lloyd,G.K.; McDonald,I.A.
参考来源:J Med Chem 1999,42(10),1684
产品链接: CAS No. 191611-76-4››