MPB-07
Chemical Name: 10-Chloro-6-hydroxybenzo[c]quinolizinium chloride
CAS No. 191091-55-1
项目整合开发状态: Biological Testing
项目研究机构: INSERM (Originator)
合成路线:The condensation of 2-methylpyridine (I) with 2,3-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III),which is cyclized by heating at 200 C.
合成路线:The condensation of 2-methylpyridine (I) with 2,6-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III),which is cyclized by heating at 200 C.
📌 参考资料/链接：
参考文献标题:CFTR channel activator cpds.and pharmaceutical compsns.containing same
文献作者:Becq,F.; Mettey,Y.; Vierfond,J.-M.; Verrier,B.; Gola,M.(CNRS (Centre National de la Recherche Scientifique))
参考来源:EP 0937044; WO 9805642
📄 详细内容
合成路线:The condensation of 2-methylpyridine (I) with 2,3-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III),which is cyclized by heating at 200 C.
合成路线:The condensation of 2-methylpyridine (I) with 2,6-dichlorobenzonitrile (II) by means of BuLi and diisopropylamine in THF gives the vinyl derivative (III),which is cyclized by heating at 200 C.
参考文献标题:Benzo[c]quinoliziums: A new family of inhibitors for protein kinase CK II
文献作者:Mettey,Y.; Vierfond,J.-M.
参考来源:Bioorg Med Chem Lett 1997,7(8),961
产品链接: CAS No. 191091-55-1››