KF-24705

Chemical Name: 1-[2-(Hydroxymethyl)-6,11-dihydrodibenzo[b,e]oxepin-11-yl]-4-phenylpiperidin-4-ol
CAS No. 188607-29-6
项目整合开发状态: Preclinical
项目研究机构: Kyowa Hakko (Originator)
合成路线:Hydroxy dibenzooxepine (I) was converted to the corresponding chloride (II) by treatment with SOCl2 in CH2Cl2.Condensation of (II) with 4-hydroxy-4-phenylpiperidine (III) produced adduct (IV).The carboxylate group of (IV) was then reduced by means of LiAlH4 in cold THF to furnish the title alcohol.