EC-665, SDZ-249-665

Chemical Name: N-[4-(2-Aminoethoxy)-3-methoxybenzyl]-N'-(4-tert-butylbenzyl)urea hydrochloride
CAS No. 189215-75-6
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:Isocyanate (II) was prepared by treatment of 4-tert-butylbenzylamine (I) with phosgene in refluxing toluene.Subsequent coupling of isocyanate (II) with 4-(2-phthalimidoethoxy)-3-methoxybenzylamine (III) furnished urea (IV).The phthaloyl protecting group was then removed by hydrazinolysis.The resulting amine was finally converted to the corresponding hydrochloride salt.