ISA-13-1
Chemical Name: 2-(2-Aminopyrimidinium-1-yl)ethylidenediphosphonic acid inner salt
CAS No. 188246-51-7
项目整合开发状态: Preclinical
项目研究机构: Yissum (Originator)
合成路线:The title compound was synthesized by nucleophilic addition of 2-aminopyrimidine (I) to vinylidene-1,1-bisphosphonic acid (II).
📌 参考资料/链接：
参考文献标题:Synthesis and preclinical pharmacology of 2-(2-aminopyrimidino) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1) - A novel biphosphonate
文献作者:Cohen,H.; Alferiev,I.S.; Monkkonen,J.; Seibel,M.J.; Pinto,T.; Ezra,A.; Solomon,V.; Stepensky,D.; Sagi,H.; Ornoy,A.; Patlas,N.; Hagele,G.; Hoffman,A.; Breuer,E.; Golomb,G.
参考来源:Pharm Res 1999,16(9),1399