FR-167344

Chemical Name: (E)-N-[N-[3-(3-Bromo-2-methylimidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichlorophenyl]-N-methylcarbamoylmethyl]-4-(N,N-dimethylcarbamoyl)cinnamamide hydrochloride
CAS No. 188550-14-3, 160644-75-7 (free base)
项目整合开发状态: Preclinical
项目研究机构: Fujisawa (Originator)
合成路线:Knoevenagel condensation of aldehyde (I) with malonic acid (II) provided substituted cinnamic acid (III).This was condensed with amino compound (IV) in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.HCl (EDC) and 1-hydroxy-benzotriazole (HOBt) to give amide (V),which was then converted to the hydrochloride salt by reaction with methanolic HCl.